The IST1 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to IST1, and IST1 factor associated with ESCRT-III. This antibody recognizes Homo Sapiens, and Human antigen. The IST1 antibody has been validated for the following applications: EIA, Immunoassay, Precipitation, ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells(PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing(PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST(PubMed:23897888)